CELSR1

edit
Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
Identifiers
SymbolsCELSR1; ME2; CDHF9; DKFZp434P0729; FMI2; HFMI2
External IDsOMIM: 604523 MGI: 1100883 HomoloGene: 7665 IUPHAR: CELSR1 GeneCards: CELSR1 Gene
RNA expression pattern
PBB GE CELSR1 41660 at tn.png
PBB GE CELSR1 204539 s at tn.png
PBB GE CELSR1 217262 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez962012614
EnsemblENSG00000075275ENSMUSG00000016028
UniProtQ9NYQ6Q571L9
RefSeq (mRNA)NM_014246NM_009886
RefSeq (protein)NP_055061NP_034016
Location (UCSC)Chr 22:
45.14 - 45.31 Mb		Chr 15:
85.73 - 85.86 Mb
PubMed search[1][2]

Cadherin EGF LAG seven-pass G-type receptor 1 is a protein that in humans is encoded by the CELSR1 gene.[1][2]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[2]

See also

References

  1. ^ Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter". Genomics 45 (1): 97-104. doi:10.1006/geno.1997.4892. PMID 9339365. 
  2. ^ a b "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620. 

Further reading

  • Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
  • Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes.". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMID 10716726. 
  • Ghosh A (2000). "Dentritic growth: don't go says flamingo.". Neuron 28 (1): 3–4. doi:10.1016/S0896-6273(00)00076-3. PMID 11086974. 
  • Gross J, Grimm O, Ortega G, et al. (2002). "Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family.". Psychiatr. Genet. 11 (4): 197–200. doi:10.1097/00041444-200112000-00003. PMID 11807409. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Georgieva L, Nikolov I, Poriazova N, et al. (2004). "Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia.". Psychiatr. Genet. 13 (2): 103–6. doi:10.1097/01.ypg.0000057486.14812.03. PMID 12782967. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Carroll JS, Liu XS, Brodsky AS, et al. (2005). "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.". Cell 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. 
Stub iconThis transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
G protein-coupled receptors, cytokine receptors: chemokine receptors
CC chemokine receptors
CXC chemokine receptors
Other
© This material from Wikipedia is licensed under the GFDL