Aniracetam

Aniracetam

Systematic (IUPAC) name
1-[(4-methoxybenzoyl)]- 2-pyrrolidinone
Identifiers
CAS number	72432-10-1
ATC code	N06BX11
PubChem	2196
ChemSpider	2111
Chemical data
Formula	C12H13NO3
Mol. mass	219.237 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	1-2.5 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Unscheduled
Routes	Oral

Aniracetam (Draganon, Sarpul, Ampamet) is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid soluble and has possible cognition enhancing effects. It has been tested in animals extensively, Alzheimer's patients and temporarily-impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. It is sold in the United States as a dietary supplement while used in Europe it is a prescription drug.

Pharmacology

After a confirmed test of the anxiolytic efficacy in a mouse model, haloperidol, mecamylamine, and ketanserin were applied to determine the pathways aniracetam depends on to exert its anti-anxiety effects. Haloperidol completely reversed the anxiolytic effects, and mecamylamine and ketanserin nearly completely reversed the effects. This shows that aniracetam's anxiolytic mechanism is facilitated by D₂/D₃, nACh, and 5-HT_2A receptors.^[1]

Aniracetam has also been shown to selectively modulate the AMPA receptor^[2] and was used as the parent compound to derive a class of drugs known as the ampakines which are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease and other neurodegenerative conditions.1

Despite the fat solubility of aniracetam its half-life is much shorter than common racetam analogs such as piracetam.

Commonly used doses are 750-3,000 mg daily usually taken in 2-3 doses.

Side effects can include nausea and headache.^{[citation needed]}

See also

• Ampakine
• Racetam
• Nootropic

References

This article needs additional citations for verification. Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (February 2010)

External links

• The Cognitive Enhancement Research Institute

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